Translation-dependent localisation of DNA loci to the membrane

The process of transertion, in which co-transcription and translation of membrane proteins could occur concomitantly with the insertion of the protein into the membrane, had been hypothesised, but never been proven (to our knowledge). In a recent paper published in PNAS, Libby and colleagues, show just that by using E. coli as the model system.

They interpret their findings in the context of its possible impact on DNA conformation:

membrane protein expression across the entire genome is likely to play a key role in shaping chromosome conformation. Our results further suggest that repositioning at any given locus is likely to be transient, occurring concomitantly with bursts of transcription. The resulting movement toward and away from the membrane at points distributed around the chromosome may be an important mechanism for maintaining the nucleoid in a sufficiently dynamic state to ensure accessibility to regulatory proteins, ribosomes, and RNA polymerase

Will this feed back to transcription? Can this feature, assuming that it is strong enough a selective force, influence gene organisation?

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